MyBotsBlog -7 days report
Chronologie Tue Jan 28 14:00:03 CET 2020
27/01/20 Pill used for nearly 40 years to treat swelling could be 'breakthrough' for children with autism | Daily Mail Online [dailymail.co]
23/01/20 Exclusion du droit des contrats en cas de violation d'une licence en droit d'auteur : quelles consequences ? Par William Mak, Avocat. [village-justice]
21/01/20 Nicole Belloubet : « La transformation numerique de la justice est synonyme d'ouverture et d'inclusion » - LE MONDE DU DROIT : le magazine des professions juridiques [lemondedudroit]

Juridique,Tendances
Exclusion du droit des contrats en cas de violation d'une licence en droit d'auteur : quelles consequences ? Par William Mak, Avocat. [village-justice]
Nicole Belloubet : « La transformation numerique de la justice est synonyme d'ouverture et d'inclusion » - LE MONDE DU DROIT : le magazine des professions juridiques [lemondedudroit]
TED,Crise/Analyse de Crise,Tendances,Lobbying/Analyse de Lobbying
Pill used for nearly 40 years to treat swelling could be 'breakthrough' for children with autism | Daily Mail Online [dailymail.co]

Juridique,Tendances
Exclusion du droit des contrats en cas de violation d'une licence en droit d'auteur : quelles consequences ? Par William Mak, Avocat. 23/01/2020

«A la suite d'un arrêt du 18 décembre 2019 (CJUE, 18 décembre 2019, C-666/18, IT Development) , la CJUE a mis un terme définitif à la possibilité de recourir aux règles de la responsabilité contractuelle de droit commun en cas de la violation d'un contrat de licence en droit d'auteur. Une telle décision est particulièrement importante puisqu'elle remet en cause nombre de règles qui était considérées jusqu'à alors parfaitement établies. Exclusion du droit des contrats en cas de violation d'une licence en droit (...) Version Imprimable»...

<< village-justice

Nicole Belloubet : « La transformation numerique de la justice est synonyme d'ouverture et d'inclusion » - LE MONDE DU DROIT : le magazine des professions juridiques 21/01/2020

«Justice.fr, le portail du justiciable, permet aux justiciables le suivi en ligne de leurs affaires civiles. Ils sont également informés des échéances de leurs affaires. En outre,100 % de la transmission des pièces aux avocats dans le cadre des affaires civiles est désormais dématérialisée. Courant 2020, justice.fr permettra la saisine en ligne dans le cadre d'une constitution de partie civile ainsi que dans le domaine de gestion des mesures de protection des majeurs et la consultation en ligne des affaires pénales»...

<< lemondedudroit

TED,Crise/Analyse de Crise,Tendances,Lobbying/Analyse de Lobbying
Pill used for nearly 40 years to treat swelling could be 'breakthrough' for children with autism | Daily Mail Online 27/01/2020


«The prescription drug that costs just a few pence improves symptoms of autism Diuretic Bumetanide used to treat heart failure and kidneys disease for decades Study of autistic children found that the drug helps nerve cells communicate Medication used to treat build up of fluid in body has 'no significant side effects' A 'water pill' used for almost four decades to treat swelling and heart failure could be a breakthrough in combating autism in children, scientists say.» [...]
« But a study of autistic children found it helps nerve cells communicate by correcting an imbalance between the brain's chemical messengers 'GABA' and 'glutamate'. What is more the medication had no significant side effects, say the British and Chinese team. Lead author Dr Fei Li of Xinhua Hospital, Shanghai, said: 'I have many children with autism spectrum disorder under my care. 'But as psychological treatment resources are not available in many places, we are unable to offer them treatment. An effective and safe treatment will be very good news for them. 'The mother of a four year old boy living in a rural area outside Shanghai who received the treatment told me that he was now better at making eye contact with family members and relatives and was able to participate more in activities. Bumetanide is a diuretic that it was found helps nerve cells among autistic children communicate by correcting an imbalance between the brain's chemical messengers (pictured a stock image) 'In future, we hope to be able to ensure all families, regardless of where they are living, can receive treatment for their child.' There are around 700,000 people with autism spectrum disorder (ASD) in the UK alone. If you include their families, it blights the daily lives of almost three million Britons. A scan called MRS (magnetic resonance spectroscopy) found the three to six year olds given bumetanide had less GABA than their peers - which improves brain function. Co-author Professor Barbara Sahakian, a psychiatrist at the University of Cambridge, said: 'I'm very excited about this. I think it could be a real breakthrough and very important for these families. 'This study is important and exciting, because it means there is a drug that can improve social learning and reduce ASD symptoms during the time when the brains of these children are still developing. 'We know GABA and glutamate are key chemicals in the brain for plasticity and learning and so these children should have an opportunity for better quality of life and wellbeing.' The ratio of GABA to glutamate decreased in two key regions - the insular cortex which plays a role in emotions, empathy and self-awareness and visual cortex that integrates and processes what we see. Too much GABA can affect the development of neurons. Intervening at an early age may prevent symptoms that make their life challenging. Prof Ching-Po Lin, of the National Yang-Ming University, Taiwan, said: 'This is the first demonstration bumetanide improves brain function and reduces symptoms by reducing the amount of the brain chemical GABA. 'Understanding this mechanism is a major step towards developing new and more effective drug treatments.' Bumetanide was first approved for use in 1983. The study published in Translational Psychiatry follows research in rats and small clinical trials suggesting it works against autism. Current treatments for children are mainly behavioural interventions, such as using play and joint activities between parents and their child to boost language, social and cognitive skills. The 83 infants were divided into two groups with 42 receiving 0.5mg dose of bumetanide twice a day for three months. The other 41 got no treatment. Autism can be reliably diagnosed as early as 18 months of age. Symptoms were assessed using the Childhood Autism Rating Scale (CARS) of imitation, emotional response and verbal and non-verbal communication. Children scoring above 30 are considered to have ASD. At the start all the children had similar CARS scores but this fell to an average of 34.51 after the therapy - compared to the control group's 37.27. Importantly, there was also a significant reduction in the number of items with a score of three or more - an average of 3.52 compared to 5.49 respectively. The discovery that bumetanide changes the relative concentrations of GABA to glutamate could also provide a useful biomarker for a drug's effect. Further studies involving a larger number of children are now needed to confirm the results, said the researchers. Many autistic people are able to lead relatively normal lives while others require support throughout. »...

<< dailymail.co


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